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基于RAFF-n的MRI造影软件

技术#z08015-20110161

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MRI SafetyMRI ContrastThis technology potentially opens up applications in gene therapy, and diagnosis of Parkinson’s disease, demyelinating neuropathies and osteoarthritis because cell densities can be differentiated more easily.This technology potentially opens up applications in gene therapy, and diagnosis of Parkinson’s disease, demyelinating neuropathies and osteoarthritis because cell densities can be differentiated more easily.
类别
研究人员
迈克尔·加伍德博士
教授,放射科,中心磁性研究
外部链接 (www.med.umn.edu)
由...管理
凯文镍
技术授权官 612-625-7289
专利保护
美国专利7932719
美国专利9222999
文件和附件
使用蜜三 - 正术语片MRI造影 [PDF]

更高MRI磁场强度降低MRI T1对比

如在临床磁共振成像(MRI)扫描仪的磁场强度的增加,图像成为经典T1加权,这是基于T1弛豫时间较不敏感。 T1加权图像通常在生物医学成像中使用,因为它固有地提供组织特异性的差异提供在图像(MRI图像中较暗和较亮的区域)的对比度。

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脉冲序列具有高的比吸收率

各种脉冲序列已经被开发来补偿这种损失在灵敏度,但其有效性已被上比吸收率(SAR)限制FDA限定。 SAR是在其能量被组织吸收的速率(实质上是组织加热的量度)和超过一定水平可导致组织损伤的量度。

改进的具有减少的特定吸收率MRI造影

The RAFF-n MRI pulse sequence creates a novel contrast using a unique relaxation time constant that reduces SAR and provides the ability to probe slow fluctuations, such as water molecules interacting strongly with macromolecules. Additionally, frequency-swept pulses utilizing RAFF-n (n>2) technology allow for systems using fields of rank n>2 to refocus magnetization and further reduce SAR. Reduced SAR allows for safe use of higher strength magnetic fields and expands the diagnostic capabilities of MRI.  The lower radio frequency (RF) power (half the peak power of adiabatic T1rho and T2rho) is safer for the subject in that it can generate less tissue heating. It also provides increased bandwidth, which can reduce certain types of image artifacts. Moreover, it generates unique contrast that enables detection of certain pathologies by providing access to different time scales of molecular dynamics. In addition to improving image contrast in classic MRI T1-weighted images, this pulse sequence potentially opens up applications in gene therapy, and diagnosis of Parkinson’s disease, demyelinating neuropathies and osteoarthritis because cell densities can be differentiated more easily. RAFF-n can accommodate a wide bandwidth that further reduces unwanted image distortion.

功能和基于RAFF-n的MRI造影好处:

  • 提高对比度机制 - 潜力扩大MRI的诊断能力。独特的固有组织对比度可以由非常慢分子动力学提供访问辅助首次某些病理的检测。
  • 减小SAR - 更少的射频(RF)功率(大约一半绝热T1R和T2R的峰值功率)。潜力,以减少在目标组织加热,使某些程序移动到FDA批准的准则
  • 为扩大MRI诊断功能 - 在基因治疗的应用,和帕金森氏病的诊断,脱髓鞘神经病变和骨关节炎
  • 减少的图像伪像 - 通过RAFF-n的增加的带宽提供

发展阶段

实验已经在3吨扫描仪和上面已经完成,能够探测到软骨退化,而其他方法不能。